Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats

Antihypertensive effect of roselle (Hibi

Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats

✍ P. C. Onyenekwe; E. O. Ajani; D. A. Ameh; K. S. Gamaniel 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB 👁 2 views

The LD 50 of roselle calyx extract and its eect on blood pressure were determined. The LD 50 was found to be above 5000 mg kg À1 . Roselle calyx infusion was found to lower signi®cantly ( p 5 0 . 05) both systolic and diastolic pressure in spontaneously hypertensive and normotensive Wistar±Kyoto rat