Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats
✍ Scribed by P. C. Onyenekwe; E. O. Ajani; D. A. Ameh; K. S. Gamaniel
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 109 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
The LD 50 of roselle calyx extract and its eect on blood pressure were determined. The LD 50 was found to be above 5000 mg kg À1 . Roselle calyx infusion was found to lower signi®cantly ( p 5 0 . 05) both systolic and diastolic pressure in spontaneously hypertensive and normotensive Wistar±Kyoto rats at tested doses of 500 and 1000 mg kg À1 body weight. The reduction in blood pressure in both groups was positively correlated with weight. Continuous consumption of the infusion at 1000 mg kg À1 was discovered to lead to sudden death in spontaneously hypertensive rats but not in Wistar-Kyoto rats. Water intake was not signi®cantly dierent ( p 4 0 . 05) in the control groups of the two strains of rats used, neither was there a signi®cant dierence in their urine output. The water intake in the treated spontaneously hypertensive and normotensive rats was not dierent from the corresponding control groups. However the urine output of the treated spontaneously hypertensive rats was signi®cantly higher. A signi®cant decrease in serum creatinine, cholesterol, and glucose in the treated rats compared with the control as well as a signi®cant increase in serum uric acid was observed. The serum proteins (albumin and total protein) in the treated rats when compared with the control groups was not changed signi®cantly.