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Sodium pump localization in epithelia

โœ Scribed by Jason S. Bystriansky; Jack H. Kaplan


Book ID
106402297
Publisher
Springer US
Year
2007
Tongue
English
Weight
131 KB
Volume
39
Category
Article
ISSN
0145-479X

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Voltage-gated, tetrodotoxin(TTX)-blockable sodium channels are found in most excitable cells and are the primary contributors to action potentials generated by many of these cells. To date, there has only been one report of a non-cultured vertebrate epithelial cell type containing TTX-blockable Na +

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In all Na(+)-absorbing and Cl(-)-secreting epithelia, an increase in the activity of the Na+,K(+)-pump at the basolateral membrane is accompanied by an increase in the K+ conductance of that barrier and vice versa. We have recently identified an ATP-regulated K+ channel, K(ATP), in basolateral membr