Sodium channels in ocular epithelia
โ Scribed by Mitchell A. Watsky; Kim Cooper; James L. Rae
- Book ID
- 104745142
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 611 KB
- Volume
- 419
- Category
- Article
- ISSN
- 0031-6768
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โฆ Synopsis
Voltage-gated, tetrodotoxin(TTX)-blockable sodium channels are found in most excitable cells and are the primary contributors to action potentials generated by many of these cells. To date, there has only been one report of a non-cultured vertebrate epithelial cell type containing TTX-blockable Na + channels: rabbit nonpigmented ciliary body epithelial cells [Cilluffo MC et al. (1991) Invest Opthalmol Vis Sci 32:1619-1629], and three reports of cultured epithelial cells containing TTXblockable Na + channels: rabbit non-pigmented and pigmented ciliary body epithelium [
๐ SIMILAR VOLUMES
In all Na(+)-absorbing and Cl(-)-secreting epithelia, an increase in the activity of the Na+,K(+)-pump at the basolateral membrane is accompanied by an increase in the K+ conductance of that barrier and vice versa. We have recently identified an ATP-regulated K+ channel, K(ATP), in basolateral membr