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Sodium channels in ocular epithelia

โœ Scribed by Mitchell A. Watsky; Kim Cooper; James L. Rae


Book ID
104745142
Publisher
Springer
Year
1991
Tongue
English
Weight
611 KB
Volume
419
Category
Article
ISSN
0031-6768

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โœฆ Synopsis


Voltage-gated, tetrodotoxin(TTX)-blockable sodium channels are found in most excitable cells and are the primary contributors to action potentials generated by many of these cells. To date, there has only been one report of a non-cultured vertebrate epithelial cell type containing TTX-blockable Na + channels: rabbit nonpigmented ciliary body epithelial cells [Cilluffo MC et al. (1991) Invest Opthalmol Vis Sci 32:1619-1629], and three reports of cultured epithelial cells containing TTXblockable Na + channels: rabbit non-pigmented and pigmented ciliary body epithelium [


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In all Na(+)-absorbing and Cl(-)-secreting epithelia, an increase in the activity of the Na+,K(+)-pump at the basolateral membrane is accompanied by an increase in the K+ conductance of that barrier and vice versa. We have recently identified an ATP-regulated K+ channel, K(ATP), in basolateral membr