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Sodium hyaluronate inhibits interleukin-1-evoked reactive oxygen species of bovine articular chondrocytes

โœ Scribed by K. Fukuda; M. Oh; S. Asada; F. Hara; M. Matsukawa; K. Otani; C. Hamanishi


Book ID
114476268
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
801 KB
Volume
9
Category
Article
ISSN
1063-4584

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Interleukin-1 beta (IL-1) is implicated in cartilage destruction in arthritis through promotion of matrix metalloproteinase production. Upregulation of collagenase gene expression by IL-1 is known to require the transactivators Fos and Jun. Recently, reactive oxygen species (ROS) have been suggested