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Sodium channel isoform-specific effects of halothane: protein kinase C co-expression and slow inactivation gating

โœ Scribed by Manoj K Patel; Dilaawar Mistry; J Edward John III; J Paul Mounsey


Book ID
110005165
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
188 KB
Volume
130
Category
Article
ISSN
0007-1188

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the