Sodium-calcium exchange and sidedness of isolated cardiac sarcolemmal vesicles
β Scribed by Donald M. Bers; Kenneth D. Philipson; Ann Y. Nishimoto
- Book ID
- 115724871
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 863 KB
- Volume
- 601
- Category
- Article
- ISSN
- 0005-2736
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π SIMILAR VOLUMES
The effects of platelet-activating factor (PAF) on Na(+)-dependent calcium uptake in myocardial sarcolemmal vesicles were examined in order to clarify its mechanism of inotropic action on the heart. PAF (40 and 20 microM) significantly inhibited Na(+)-Ca2+ exchange by 61% and 37%, respectively. Both
SUMMARY> A tightly-sealed cardiac sarcolen=~l patch preparation of large diameter (10-16 /zm with 5-25 GQ seats] has been developed to study regulation of selected electrogenic mechanisms. Formation of a large readily accessible membrane surface area is achieved by incubating freshly isolated myocyt