✦ LIBER ✦

Sodium bis(2-methoxyethoxy)(1,1,1,3,3,3-hexafluoro-2-propoxy)aluminum hydride, a new stereoselective reducing agent in a carbacyclin synthesis

✍ Scribed by Susumu Harashima; Osamu Oda; Shigeo Amemiya; Koichi Kojima

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 793 KB
Volume: 47
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)87084-8

No coin nor oath required. For personal study only.

✦ Synopsis

A new reducing agent (2j) reduced the enone (4) to give 15(S)-allylic alcohol (5a) with excellent regio-and stereoselectivity through a five membered ring transition state. Stereoselectivity of this reaction will be explained based on the LUMO of the enone moiety. The resulting (5a) was led to a carbacyclin.

📜 SIMILAR VOLUMES

Sodium Bis(2-methoxyethoxy)aluminum Hydr

Sodium Bis(2-methoxyethoxy)aluminum Hydride in Reactions with 3-Cyano-6-methylpyridine-2(1H)-thione and 3-Cyano-6-methyl(4,6-dimethyl)-2-methylthiopyridines

✍ A. A. Zubarev; V. K. Zav'yalova; V. P. Litvinov 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 109 KB 👁 1 views

1,1,1,3,3,3-Hexafluoro-2-propyl group as

1,1,1,3,3,3-Hexafluoro-2-propyl group as a new phosphate protecting group for oligoribonucleotide synthesis in the phosphotriester approach

✍ Shunichi Yamakage; Masayo Fujii; Hiroshi Takaku; Masaru Uemura 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 508 KB

The 1,1,1,3,3,3-Hexafluoro-2-propyl group can be used as a new class of phosphate protecting group for the protecting group of internucleotidic bonds in the oligonucleotide synthesis by the phosphotriester approach . This protecting group is removed easily by treatment with 0 .3 M N 1 ,N 1 ,N 3 ,N''

A new method for preparation of 3,6-dihy

A new method for preparation of 3,6-dihydro-2H-1,3-oxazines and explorations of their use in stereoselective synthesis of 1,3-amino alcohol derivatives

✍ John P. Cherkauskas; Andrew M. Klos; Robert M. Borzilleri; Joseph Sisko; Steven 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 919 KB

A new stereoselective approach for the s

A new stereoselective approach for the synthesis of substituted 3-cyclopropylmethylene-1,3-dihydro-indol-2-one via the condensation reaction of cis-1-aryl-2-benzoyl-3,3-dicyanocyclopropanes with oxindole in water

✍ Dong Zhou; Haigang Yu; Ying Liu; Jie Chen; Hongmei Deng; Min Shao; Zhongjiao Ren 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 243 KB

ChemInform Abstract: A New Stereoselecti

ChemInform Abstract: A New Stereoselective Approach for the Synthesis of Substituted 3-Cyclopropylmethylene-1,3-dihydro-indol-2-one via the Condensation Reaction of cis-1-Aryl-2-benzoyl-3,3-dicyanocyclopropanes with Oxindole in Water.

✍ Dong Zhou; Haigang Yu; Ying Liu; Jie Chen; Hongmei Deng; Min Shao; Zhongjiao Ren 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Stannes in synthesis: A new route to 2-s

Stannes in synthesis: A new route to 2-substituted-1,3-butadienes via stereoselective allyltin formation under homolytic conditions

✍ Yoshio Ueno; Hiroshi Sano; Seiichi Aoki; Makoto Okawara 📂 Article 📅 1981 🏛 Elsevier Science 🌐 French ⚖ 202 KB

a-(Hydroxymethyl)allyl tolylsulfones reacted with tributyltin hydride in the presence of azobisisobutyronitrile(AIBN) in refluxing benzene to give a allyltin derivatives which subsequently gave 2-substituted-1,3-butadienes upon distillation in good yield.