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Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death

✍ Scribed by Sreekumar Othumpangat; Michael Kashon; Pius Joseph

Publisher: Springer
Year: 2005
Tongue: English
Weight: 268 KB
Volume: 279
Category: Article
ISSN: 0300-8177
DOI: 10.1007/s11010-005-8284-2

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## BACKGROUND. When resting cells are stimulated by growth factors, an increase in protein synthesis follows that depends in part on two key eukaryotic translation initiation factors, 4E and 2␣ (eIF-4E and eIF-2␣, respectively). In the normal cell, expression and activity of both factors are incre