The expression and the clinical significance of eukaryotic translation initiation factors 4E and p53 in squamous cell carcinoma
โ Scribed by Shenqiu Li; Qinjing Wei
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 141 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1610-1979
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We examined the frequency of p53 mutations in 38 oropharyngeal squamous cell carcinomas (SCC), using both a yeast functional assay and a conventional immunohistochemical staining method (IHC) to detect p53 mutations.We also explored the clinical importance of p53 mutations in oropharyngeal SCC. An a
## Background and objectives: It is generally accepted that the overexpression of p53 protein is associated with poor prognosis in breast, colorectal, and other types of cancer. however, the prognostic significance of p53 aberrations in esophageal squamous cell carcinoma has yet to be determined. w