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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

โœ Scribed by Iadecola, Costantino; Zhang, Fangyi; Niwa, Kiyoshi; Eckman, Chris; Turner, Sherry K.; Fischer, Elizabeth; Younkin, Steven; Borchelt, David R.; Hsiao, Karen K.; Carlson, George A.


Book ID
109826736
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
193 KB
Volume
2
Category
Article
ISSN
1097-6256

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Endothelial cell dysfunction in response
โœ Nadia Jahroudi; Jana Kitney; Joel S. Greenberger; Robert Bowser ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 928 KB

Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (Aโค) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic