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Endothelial cell dysfunction in response to intracellular overexpression of amyloid precursor protein

✍ Scribed by Nadia Jahroudi; Jana Kitney; Joel S. Greenberger; Robert Bowser

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 928 KB
Volume: 54
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19981215)54:6<828::aid-jnr11>3.0.co;2-m

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✦ Synopsis

Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (A␤) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic endothelial cells but not to bovine aortic smooth muscle cells. Intracellular coexpression of the free radical scavenger proteins metallothionein or MnSOD abolished the toxic effect of APP overexpression in endothelial cells. Our results demonstrate that endothelial cells are specifically susceptible to intracellular overexpression of APP and free radical generation is the likely mechanism of cell damage due to APP overexpression.

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