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SOD1 mutant protein gets loose in ALS

✍ Scribed by Pat McCaffrey


Book ID
114408227
Publisher
The Lancet
Year
2006
Tongue
English
Weight
37 KB
Volume
5
Category
Article
ISSN
1474-4465

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## Abstract Amyotrophic lateral sclerosis (ALS) is caused by the progressive degeneration of motor neurons. Mutations in the Cu/Zn superoxide dismutase (SOD1) are found in approximately 20% of patients with familial ALS. Mutant SOD1 causes motor neuron death through an acquired toxic property. Alth