No coin nor oath required. For personal study only.
index. Splenocytes were harvested from test and control mice 2 weeks following PT removal. Antitumour cytotoxicity assessed by co-culturing splenocytes with viable 3LL tumour cells. Tumour cell death was assessed using Cytoxilux fluorogenic caspase assay. P < 0โข05 using ANOVA. Results: Following tumour removal pulmonary metastatic burden was significantly reduced in DC treatment groups (1โข9(0โข8) control versus 1โข2(0โข45) treatment) resembling that of mice that did not undergo PT removal (1โข2(0โข45) versus 1โข1(0โข3); P = 0โข34). Vaccine-activated splenocytes stimulated T cell proliferation significantly enhancing anti-3LL cell T lymphocyte cytotoxicity (81(10) versus 49( 16) per cent control). Conclusion: Perioperative vaccination protects against surgically induced activation of dormant micrometastases.
๐ SIMILAR VOLUMES
Background: Ischaemia-reperfusion injury (IRI) is a major cause of morbidity which may be minimized by pharmacological preconditioning. Calcium has been shown to protect cardiac muscle from IRI as well as from arrhythmia related to hyperkalaemia. Cromakalim (K + channel opener) was shown to preserve