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SMAR1 Forms a Ternary Complex with p53-MDM2 and Negatively Regulates p53-mediated Transcription

✍ Scribed by Lakshminarasimhan Pavithra; Srijata Mukherjee; Kadreppa Sreenath; Sanchari Kar; Kazuyasu Sakaguchi; Siddhartha Roy; Samit Chattopadhyay


Book ID
116664087
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
588 KB
Volume
388
Category
Article
ISSN
0022-2836

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## Abstract We report that MDM2, a negative regulator of p53, can bind to EBNA‐5. Using GST pull‐down assay, immunoprecipitation, surface plasmon resonance and immunostaining of lymphoblastoid cells, we found that trimolecular complexes are formed between EBNA‐5, MDM2 and p53, where MDM2 serves as