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ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage

✍ Scribed by Heo, Jee-In; Oh, Soo-Jin; Kho, Yoon-Jung; Kim, Jeong-Hyeon; Kang, Hong-Joon; Park, Seong-Hoon; Kim, Hyun-Seok; Shin, Jong-Yeon; Kim, Min-Ju; Kim, Minju; Kim, Sung Chan; Park, Jae-Bong; Kim, Jaebong; Lee, Jae-Yong


Book ID
113076107
Publisher
Springer
Year
2012
Tongue
English
Weight
470 KB
Volume
39
Category
Article
ISSN
0301-4851

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## Abstract The p53 tumor suppressor protein is a critical mediator of cell cycle arrest and apoptosis in response to genotoxic stress. Abrogation of p53 function is a major feature of tumor development and may result in a compromised DNA‐damage response. In our study, we examined the effect of exp