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Small molecule inhibition of hepatitis C virus E2 binding to CD81

✍ Scribed by Scott E VanCompernolle; Alexander V Wiznycia; Jeremy R Rush; Muthu Dhanasekaran; Paul W Baures; Scott C Todd

Book ID
114093280
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
387 KB
Volume
314
Category
Article
ISSN
0042-6822

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✍ Elisabetta Soldaini; Andreas Wack; Ugo D'Oro; Sandra Nuti; Cristina Ulivieri; Co πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 371 KB

## Abstract Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory signal for human T cells. This phenomenon may play a role in liver damage and autoimmune manifestations associated with HCV infection. Here we show that cross‐linking of CD81 by HCV E2 induced a