## Abstract ## Background Small interfering (si)RNA mediated inhibition of oncogenes or viral genes may offer great opportunities for the treatment of several diseases such as hepatocellular carcinoma and viral hepatitis. However, the development of siRNAs as therapeutic agents strongly depends on
β¦ LIBER β¦
Small interfering RNA delivery and gene silencing using polymeric nanocarrier systems
β Scribed by K. A. Howard; X. Liu; D. Oupicky; S. Zoffmann; F. Besenbacher; J. Kjems
- Book ID
- 107574832
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 58 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1551-1286
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## Abstract ## Background A variety of synthetic carriers, such as cationic polymers and lipids, have been used as nonviral carriers for small interfering RNA (siRNA) delivery. Although siRNA polyplexes and lipoplexes exhibited good gene silencing efficiencies, they often showed serious cytotoxici
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