Small heparin fragments regulate the amplification pathway of complement
โ Scribed by Murali D. Sharath; Zohar M. Merchant; Yeong S. Kim; Kevin G. Rice; Robert J. Linhardt; John M. Weiler
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 586 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0162-3109
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## Abstract Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surface of activating substances. Using sulfated polyanions as model substances, an efficient fluidโpha
The luminal surfaces of polyethylene and polyurethane tubings of 1 mm inner diameter and 1 m in length were coated with heparin by end point attachment and thereafter sterilized in ethylene oxide. The tubings were inserted as arterio-venous shunts from the aorta to the superior caval vein via a caro