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Small cytokine superfamily
โ Scribed by Barbara Sherry; Anthony Cerami
- Book ID
- 103972800
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 628 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
โฆ Synopsis
Proteins comprising a newly described superfamily of small inducible cytokines (tentatively designated 'scy') exhibit considerable similarity with respect to activity, regulation and genomic structure. Recent observations, however, have identified specific biological activities and contexts in which these cytokines differ and which may allow fine tuning of immune and inflammatory responses.
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The recent successful introduction of the anti-cytokine biologicals Etanercept, Infliximab, Adalimumab, and Anakinra has stimulated the search for anti-cytokine small-molecules. A number of molecular targets have been identified for the development of such small molecular anti-cytokine agents. The f