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Activation of the Ras superfamily of small GTPases

✍ Scribed by Zheng, Yi; Quilliam, Lawrence A.

Book ID
110033610
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
169 KB
Volume
4
Category
Article
ISSN
1469-221X

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Biologically active forms of Ras complexed to GTP can bind to the GTPase-activating protein (GAP), which has been implicated as possible target of Ras in mammalian cells. In order to study the structural features of Ras required for this interaction, we have evaluated a series of mutant ras proteins

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## Abstract Members of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle between active GTP‐complexed and inactive GDP‐complexed states. Guanine nucleotide exchange factors (GEFs) stimulate formation of the GTP‐bound state, whereas GTPase activating proteins (GAPs) c