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Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis

โœ Scribed by Canman, Christine E; Kastan, Michael B


Book ID
110061168
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
456 KB
Volume
16
Category
Article
ISSN
0950-9232

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p53 plays a critical role as a tumour-suppressor in restricting the proliferation of damaged cells, thus preventing formation of genetically altered cell clones. Its inactivation leads, in particular, to accumulation of polyploid and aneuploid cells. To elucidate the role of p53 in control of chromo