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Small Cell Lung Cancer: Significance of RB Alterations and TTF-1 Expression in its Carcinogenesis, Phenotype, and Biology

✍ Scribed by Hitoshi Kitamura; Takuya Yazawa; Hanako Sato; Koji Okudela; Hiroaki Shimoyamada


Book ID
107571847
Publisher
Springer US
Year
2009
Tongue
English
Weight
256 KB
Volume
20
Category
Article
ISSN
1046-3976

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## Inactivation of the Rb pathway in non-small cell lung carcinoma (NSCLC) occurs mostly through inactivation of the cyclin-dependent kinase inhibitor p16 INK4A and/or up-regulation of cyclin D1. In order to assess the frequency and the prognostic value of these abnormalities in NSCLC, immunohisto