Smad3-Dependent Induction of Plasminogen Activator Inhibitor-1 in Astrocytes Mediates Neuroprotective Activity of Transforming Growth Factor-β1 against NMDA-Induced Necrosis
✍ Scribed by Fabian Docagne; Olivier Nicole; Cecilia Gabriel; Mónica Fernández-Monreal; Sylvain Lesné; Carine Ali; Laurent Plawinski; Peter Carmeliet; Eric T. MacKenzie; Alain Buisson; Denis Vivien
- Book ID
- 115637931
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 304 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1044-7431
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Basic fibroblast growth factor (bFGF) and transforming growth factor‐β1 (TGF‐β1) play an important role in proliferation, differentiation, and survival of malignant gliomas and in normal glial cell biology. Because of these critical roles, potential interactions between these key growth
## Abstract The net balance between urokinase‐type plasminogen activator (uPA) and plasminogen activator inhibitor type‐1 (PAI‐1) has been implicated in tumor cell invasion and metastasis. To elucidate the mechanism of the transforming growth factor‐β1 (TGF‐β1)‐dependent up‐regulation of PAI‐1 expr