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Sloppier copier DNA polymerases involved in genome repair

✍ Scribed by Myron F Goodman; Brigette Tippin


Book ID
117654640
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
220 KB
Volume
10
Category
Article
ISSN
0959-437X

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## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint