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Slippage-misalignment; a ubiquitious mechanism of gene mutation in mammalian cells

โœ Scribed by T. Kato; H. Ogawa; H. Kimura


Book ID
113253115
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
177 KB
Volume
334
Category
Article
ISSN
0165-1161

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## Abstract A set of mutated SV40 early polyadenylation signals (SV40pA) with varying strengths is generated by mutating the AATAAA sequence in the wildโ€type SV40pA. They are shown to control the expression level of a gene over a 10โ€fold range using luciferase reporter genes in transient transfecti