✦ LIBER ✦

Skin manifestation of agnogenic myeloid metaplasia

✍ Scribed by Gabriel Loewy; Anna Mathew; Ariel Distenfeld

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 449 KB
Volume: 45
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830450213

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✦ Synopsis

Agnogenlc myeloid metaplasla (AMN) with myeloflbrosis is a clonal malignancy of the hematopoletic stem cell. The disease is characterized by Increased endothelial cell and fibroblast proliferation, resulting in Increased deposition of flbronectln, lamlnln, and collagen in the bone marrow. In advanced disease, extramedullary hematopoiesis (EMH) is invariably seen In the spleen and liver. The lymph nodes are also frequent sites of EMH, but other organs, especially the kidneys, arenals, lungs, pleura, ovaries, gastrointestinal tract, and dura, may also be Involved. Skin manifestations are rare. They may present in several ways: erythematous plaques, nodules, diffuse or papular erythema, ulcers, and bullae. Histopathology of these lesions reveals cells from one or more myeloid lineage in the dermis, erythrold, or megakaryocytic series alone or In combination. In rare cases, all three cell lines are demonstrated. o iw W~IOY-USS, in^.

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