Skeletal muscle metastasis in a patient with wilms tumor and multiple late recurrences

✍ Scribed by Sreedhar P. Rao; Scott T. Miller; Monika Wrzolek; Jack O. Haller; Donald Klotz

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 765 KB
• Volume: 71
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19930215)71:4<1343::aid-cncr2820710428>3.0.co;2-l

✦ Synopsis

Stage I11 Wilms tumor was diagnosed in a 9-year-old girl. Four and a half years after the treatment, which consisted of an operation, radiation therapy, and chemotherapy, the patient had a solitary metastasis in the liver, which was successfully treated with chemotherapy and surgical resection. Five years later, right lung metastases were eradicated by chemotherapy, radiation, and surgical resection. Three and a half years later, she had a metastasis in the left calf, for which she underwent surgical resection and received chemotherapy. This patient has several interesting features: (1) multiple recurrences, two in the usual sites of metastasis and one in an extremely rare site, i.e., skeletal muscle; (2) long intervals between recurrences; and (3) unusual histopathologic features, i.e., gradual evolution from a triphasic Wilms tumor at the primary site, to a predominance of differentiated mucinous epithelium in the skeletal muscle metastasis. Cancer 1993; 71:1343-7.