Bone marrow micrometastases in a patient with localized Wilms' tumor

✍ Scribed by Dominici, Carlo; Gregory, Silvia; Padula, Anthony; Fares, Cristina; Ceccamea, Alberto; Castello, Manuel A.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 460 KB
• Volume: 26
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199602)26:2<125::aid-mpo10>3.0.co;2-h

✦ Synopsis

The case of a 7-year-old boy presenting at diagnosis with a localized (stage 111) Wilms' tumor of favorable histology is presented. lmmunocytologic analysis of bone marrow aspirates revealed cells positive for neural cell adhesion molecule (NCAM) and negative for class I major histocompatibility complex (MHC) antigens. These cells were interpreted as deriving from the tumor blaste-ma1 component. Postoperatively the child underwent radiotherapy and chemotherapy, and he remains free of disease 12 months after completion of therapy. In patients with nonmetastatic Wilms' tumor at onset, the evaluation of the actual frequency of occult marrow involvement and the assessment of its clinical significance may necessitate further investigation.