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Skeletal muscle metabolism in physiology and in cancer disease

✍ Scribed by Anna Giordano; Menotti Calvani; Orsolina Petillo; Maria Carteni'; Maria Rosa A.B. Melone; Gianfranco Peluso

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 573 KB
Volume: 90
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10601

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✦ Synopsis

Abstract

Skeletal muscle is a tissue of high demand and it accounts for most of daily energy consumption. The classical concept of energy metabolism in skeletal muscle has been profoundly modified on the basis of studies showing the influence of additional factors (i.e., uncoupling proteins (UCPs) and peroxisome proliferator activated receptors (PPARs)) controlling parameters, such as substrate availability, cellular enzymes, carrier proteins, and proton leak, able to affect glycolysis, nutrient oxidation, and protein degradation. This extremely balanced system is greatly altered by cancer disease that can induce muscle cachexia with significant deleterious consequences and results in muscle wasting and weakness, delaying or preventing ambulation, and rehabilitation in catabolic patients. J. Cell. Biochem. 90: 170–186, 2003. © 2003 Wiley‐Liss, Inc.

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