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Akt/protein kinase B in skeletal muscle physiology and pathology

✍ Scribed by Miaozong Wu; Marco Falasca; Eric R. Blough

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
135 KB
Volume
226
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while Akt over‐activation has been linked to inappropriate cell growth and proliferation. Although the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer. J. Cell. Physiol. 226: 29–36, 2010. © 2010 Wiley‐Liss, Inc.

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