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We aimed to verify how granule cells of two post-natal ages (6 and 10 days) modify quantitatively and whether their parameters get close to those of a younger age (2 months) of an adult age spectrum already studied. In semithin sections, we estimated the mean volume (V N ) of the nucleus using the ratio: nuclear volume density (V v ) / nuclear numerical density (N v ). In electron micrographs, we calculated the V v of cytoplasm, mitochondria, Golgi complex, cytosol, and the surface density (S v ) and absolute surface (S) of rough endoplasmic reticulum (RER). These values permitted the estimation of absolute values (V) and the somatic mean volume (V N ). At 6 days, the nuclear V N was 196 µm 3 and at 10 days was 113 µm 3 . At 6 days, the V N of the soma was 291µm 3 and at 10 days was 156 µm 3 . Significant differences were also exhibited by the V of cytoplasmic components, and the S of RER. The comparison 10 days versus 2 months detected no significant differences in the nuclear or somatic V N , in the V of cytoplasm, of mitochondria, of cytosol and in the S of RER. It was concluded that, under this stereological study, granule cells of 10 days are already similar to the younger adult ones. Supported by the FCT and the Eng. António de Almeida Foundation.
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