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Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann–Pick disease type C mouse brain

✍ Scribed by Miyako Taniguchi; Yoko Shinoda; Haruaki Ninomiya; Marie T. Vanier; Kousaku Ohno

Book ID
117545467
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
705 KB
Volume
23
Category
Article
ISSN
0387-7604

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## Abstract Niemann‐Pick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomal–lysosomal system. Most studies on the mechanisms of neurodegenera