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Site-specific opening of the blood-brain barrier

✍ Scribed by Steen J. Madsen; Henry Hirschberg

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
364 KB
Volume
3
Category
Article
ISSN
1864-063X

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✦ Synopsis

Abstract

The blood‐brain barrier (BBB) poses a significant impediment for the delivery of therapeutic drugs into the brain. This is particularly problematic for the treatment of malignant gliomas which are characterized by diffuse infiltration of tumor cells into normal brain where they are protected by a patent BBB. Selective disruption of the BBB, followed by administration of anti‐cancer agents, represents a promising approach for the elimination of infiltrating glioma cells. A summary of the techniques (focused ultrasound, photodynamic therapy and photochemical internalization) for site‐specific opening of the BBB will be discussed in this review. Each approach is capable of causing localized and transient opening of the BBB with minimal damage to surrounding normal brain as evidenced from magnetic resonance images and histology. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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## Abstract Few terms in the biomedical lexicon are as widely recognized as the phrase blood–brain barrier (BBB). Indeed, it immediately conjures up a “barricade” between the blood and the brain, a feature often considered more obstacle than safeguard. In truth, the BBB performs in both capacities,