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Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication

✍ Scribed by T. Kohashi; S. Maekawa; N. Sakamoto; M. Kurosaki; H. Watanabe; Y. Tanabe; C.-H. Chen; N. Kanazawa; M. Nakagawa; S. Kakinuma; T. Yamashiro; Y. Itsui; T. Koyama; N. Enomoto; M. Watanabe


Book ID
108885896
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
699 KB
Volume
13
Category
Article
ISSN
1352-0504

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Amino acid (aa) mutations in the interferon-sensitivity determining region (ISDR) (aa position 237-276 of the nonstructural region 5A [NS5A] protein consisting of 447 amino acids) of hepatitis C virus (HCV) are related to increased interferon sensitivity and low viral load, but its mechanism has not