Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication
β Scribed by T. Kohashi; S. Maekawa; N. Sakamoto; M. Kurosaki; H. Watanabe; Y. Tanabe; C.-H. Chen; N. Kanazawa; M. Nakagawa; S. Kakinuma; T. Yamashiro; Y. Itsui; T. Koyama; N. Enomoto; M. Watanabe
- Book ID
- 108885896
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 699 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1352-0504
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## Abstract The degree of variability of the interferon sensitivity determining region (ISDR) in the hepatitis C virus (HCV) genome has been postulated to predict the response to interferon therapy, mainly in patients infected with subtype 1b, although this prediction has been the subject of a long
Amino acid (aa) mutations in the interferon-sensitivity determining region (ISDR) (aa position 237-276 of the nonstructural region 5A [NS5A] protein consisting of 447 amino acids) of hepatitis C virus (HCV) are related to increased interferon sensitivity and low viral load, but its mechanism has not