## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNAโdependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire
Mutations in interferon sensitivity- determining region of hepatitis C virus: its relation to change in viral load
โ Scribed by Yasuyuki Terazawa; Kentaro Yoshioka; Makoto Kobayashi; Kazumasa Watanabe; Masatoshi Ishigami; Motoyoshi Yano; Kenji Takagi; Shinichi Kakumu
- Book ID
- 119388975
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 163 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-9270
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Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up
Amino acid (aa) mutations in the interferon-sensitivity determining region (ISDR) (aa position 237-276 of the nonstructural region 5A [NS5A] protein consisting of 447 amino acids) of hepatitis C virus (HCV) are related to increased interferon sensitivity and low viral load, but its mechanism has not
## Abstract The interferon sensitivityโdetermining region (ISDR) is thought to be inhibited by the doubleโstranded RNAโdependent protein kinase (PKR). Several studies have reported a relationship between the ISDR and interferon (IFN) responsiveness. However, this relationship is controversial. The
## Abstract The degree of variability of the interferon sensitivity determining region (ISDR) in the hepatitis C virus (HCV) genome has been postulated to predict the response to interferon therapy, mainly in patients infected with subtype 1b, although this prediction has been the subject of a long