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Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum

✍ Scribed by Robert I. Grundy; Nancy J. Rothwell; Stuart M. Allan

Book ID
113997785
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
273 KB
Volume
926
Category
Article
ISSN
0006-8993

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Varied actions of proinflammatory cytoki
Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system
✍ Stuart M. Allan πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 354 KB πŸ‘ 1 views

## Abstract Interleukin (IL)‐1Ξ² mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) in the rat brain. The objective of this study was to determine whether this effect was

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Excitotoxic brain damage in the rat induces interleukin-1Ξ² protein in microglia and astrocytes: Correlation with the progression of cell death
✍ Victoria Louise Pearson; Nancy Jane Rothwell; Sylvie Toulmond πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 552 KB

Interleukin-1 beta (IL-1␀) has been proposed as a mediator of several forms of brain damage, including that induced by excitotoxins. In vitro studies suggest that glial cells are the effector cells of IL-1␀-mediated neurodegeneration. We have investigated the expression of IL-1␀ protein by glial cel