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Site-selective Sonogashira reactions of 1,2-dibromo-3,5-difluorobenzene

✍ Scribed by Sebastian Reimann; Peter Ehlers; Muhammad Sharif; Kai Wittler; Anke Spannenberg; Ralf Ludwig; Peter Langer


Book ID
116343864
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
706 KB
Volume
25
Category
Article
ISSN
1566-7367

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Site-Selective Sonogashira Reactions of
✍ Sebastian Reimann; Muhammad Sharif; Martin Hein; Alexander Villinger; Kai Wittle 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 891 KB

## Abstract A variety of alkynyl‐substituted fluorinated benzene derivatives have been prepared by Sonogashira cross‐coupling reactions of 1,4‐dibromo‐2‐fluorobenzene. The reactions proceed with very good site‐selectivity in favor of the 4‐position because of electronic and steric reasons. The regi