Sister chromatid exchanges in adult epileptic patients on phenytoin therapy
β Scribed by Schaumann, Blanka ;Johnson, Sue Barden ;Wang, Nancy ;van Brunt, Suzanne
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1985
- Weight
- 248 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0192-2521
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Phenytoin (PHT) is a widely prescribed antiepileptic drug. Its potential to interact with genetic material was investigated in a set of 30 epileptic patients (age 10-30 years) prior to and following the administration of PHT over a period of 9 months (grouped in a multiple of 3 months) and 40 contro
The frequency of SCE was investigated in peripheral lymphocytes of one patient with XP. Although lymphocytes did not show high levels of spontaneous chromosome damage, 10-s M Mitomycin C greatly increased the fi'equency of SCE, The results are interpreted as an expression of mutagen induced chromoso