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Sister chromatid exchanges and aging

✍ Scribed by Edward L. Schneider; Brian Gilman

Publisher
Springer
Year
1979
Tongue
English
Weight
395 KB
Volume
46
Category
Article
ISSN
0340-6717

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✦ Synopsis

Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, a significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.

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