Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age, and lifestyle

✍ Scribed by Roberto Barale; Linda Chelotti; Tania Davini; Silvia Del Ry; Maria Grazia Andreassi; Michela Ballardin; Maria Bulleri; Jiling He; Silvia Baldacci; Francesco Di Pede; Federica Gemignani; Stefano Landi

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 297 KB
• Volume: 31
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/(sici)1098-2280(1998)31:3<228::aid-em4>3.0.co;2-g

✦ Synopsis

Sister chromatid exchange (SCE) and micronuclei cation of mean values of SCEs. Multiple logistic re-(MN) analysis was carried out on 1,650 healthy gression analysis revealed a statistically significant individuals living in Pisa and in two nearby small association between the proportion of high frecities, Cascina and Navacchio (Ca-Na). The effect quency cells (HCF) outliers and coffee consumption. of smoking on SCEs was linearly correlated with Age and sex appeared to be by far the most imthe number of cigarettes per day, and an increase portant variables associated with modifications in of 7.3% SCEs was detectable for as few cigarettes MN frequency, which increased by 0.04‰ and as 1-10/day. Ex-smokers showed intermediate 0.02‰ per year in males and females, respecmean values of SCEs (8.09 { 1.88) in comparison tively. Children and young donors (age °40 years) with never smokers (7.54 { 1.61) and current showed lower MN frequency regardless of sex, smokers (8.45 { 1.94). Mean values of SCEs of whereas sex appeared to determine a significantly ex-smokers decreased linearly with time of smoking higher increase of MN only in females older than cessation, reaching the mean values of never smok-40 years. In contrast, in males the MN rate by age ers within 8 years. The extent of SCE decrease was tended to level off after the age of 30-50. MN inversely proportional to the number of cigarettes frequencies of Pisa blue-and white-collar workers previously smoked. No interaction between smok-were statistically significantly higher than in students ing habits and coffee or alcohol drinking on SCEs (/0.71 and /0.55‰, respectively). Smoking did was observed. A borderline (P Å 0.053) increase not determine any increase of MN frequency. A in mean SCE values in coffee drinkers (more than total lack of correlation (P Å 0.913) between MN 3 cups/day) was found. The age effect on SCEs and SCEs was observed.