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Sirtuins: NAD+-dependent deacetylase mechanism and regulation

✍ Scribed by Sauve, Anthony A; Youn, Dou Yeon

Book ID
118427740
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1014 KB
Volume
16
Category
Article
ISSN
1367-5931

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Histone deacetylases (HDACs) are enzymes that cleave off acetyl groups from acetyl-lysine residues in histones and various nonhistone proteins. Four different classes of HDACs have been identified in humans so far. Although classes I, II, and IV are zinc-dependent amidohydrolases, class III HDACs de