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ChemInform Abstract: NAD+-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

โœ Scribed by Joerg Schemies; Urszula Uciechowska; Wolfgang Sippl; Manfred Jung


Publisher
John Wiley and Sons
Year
2010
Weight
20 KB
Volume
42
Category
Article
ISSN
0931-7597

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NAD+-dependent histone deacetylases (sir
โœ Jรถrg Schemies; Urszula Uciechowska; Wolfgang Sippl; Manfred Jung ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 418 KB

Histone deacetylases (HDACs) are enzymes that cleave off acetyl groups from acetyl-lysine residues in histones and various nonhistone proteins. Four different classes of HDACs have been identified in humans so far. Although classes I, II, and IV are zinc-dependent amidohydrolases, class III HDACs de