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siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats

✍ Scribed by George, J; Tsutsumi, M


Book ID
110039975
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
1024 KB
Volume
14
Category
Article
ISSN
0969-7128

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## Abstract ## Background Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to silence gene expression post‐transcriptionally. Therefore, we conducted an investigation to determine if int