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Inhibition of Connective Tissue Growth Factor by Small Interfering RNA Prevents Renal Fibrosis in Rats Undergoing Chronic Allograft Nephropathy

✍ Scribed by G.H. Luo; Y.P. Lu; J. Song; L. Yang; Y.J. Shi; Y.P. Li

Book ID
116934594
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
362 KB
Volume
40
Category
Article
ISSN
0041-1345

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## Abstract ## Background Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to silence gene expression post‐transcriptionally. Therefore, we conducted an investigation to determine if int