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Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvement and a therapeutic response to vinblastine-loaded platelets

✍ Scribed by Neal S. Penneys; Yeon S. Ahn; E. Churchill McKinney; Thomas McCleod; Gerald Byrne Jr; John Byrnes; Mehrdad Nadji

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 599 KB
Volume: 49
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19820515)49:10<1994::aid-cncr2820491008>3.0.co;2-t

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✦ Synopsis

A patient with sinus histiocytosis with massive lymphadenopathy had unusual skin lesions and progressive internal involvement. Both aspects responded dramatically to the administration of vinblastine-loaded platelets. Vinblastine-loaded, idiopathic thrombocytopenic purpura antibody-coated platelets are a rationale therapy for a disease characterized by the presence of actively phagocytosing histiocytes.

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