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Sinus histiocytosis with massive lymphadenopathy (rosai-dorfman disease): Diagnosis with fine-needle aspiration in a case with nodal and nasal involvement

✍ Scribed by Ramiro Alvarez Alegret; Amelia Martinez Tello; Teresa Ramirez; Paz Gállego; David Martinez; Gregorio García Julián

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
424 KB
Volume
13
Category
Article
ISSN
8755-1039

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✦ Synopsis

Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the prolifration of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle aspiration (FNA) of a cervical node. The smears show a background of lymphocytes and plasma cells and large histiocytes with well-preserved bmphocytes iil their cytoplasm (emperiplesis or lymphophagocytosis). Both nodal and extranodal (nasal mass) involvement are conjrmed by surgical biopsy. The immunohistochemistry suggests that SHML cells are functionally activated macrophages. Eight months after diagnosis, the patient is clini-

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✍ Bipin Kumar; Smriti Karki; Punam Paudyal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 2 views

## Abstract Sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) is a rare benign disease of unknown etiology presenting with massive lymphadenopathy. We report four cases of this disease retrieved from the archives of cytopathology laboratory, BPKIHS, Dharan, Nepal, during the