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Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse

✍ Scribed by Elvira Escribano; Xavier García Sala; Jorge Salamanca; Claudia Roig Navarro; Josep Queralt Regué

Book ID
118454290
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
486 KB
Volume
436
Category
Article
ISSN
0378-5173

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Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P\*eff) by measur