Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P\*eff) by measur
โฆ LIBER โฆ
Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model
โ Scribed by Araz A. Raoof; Jackie Butler; John G. Devane
- Book ID
- 110305328
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 301 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0724-8741
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In situ and in vitro intestinal absorption in the rat ileum was systematically studied and mechanistically quantified in terms of permeability coefficients (P) of a series of [(3)H]steroids as model transcellular permeants, [(3)H]taurocholate utilizing the active membrane transport systems to define