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In Vitro and In Situ Absorption of SDZ-RAD Using a Human Intestinal Cell Line (Caco-2) and a Single Pass Perfusion Model in Rats: Comparison with Rapamycin

✍ Scribed by Andrew Crowe; Michel Lemaire


Book ID
110307609
Publisher
Springer US
Year
1998
Tongue
English
Weight
643 KB
Volume
15
Category
Article
ISSN
0724-8741

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Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P\*eff) by measur